61439-59-6Relevant articles and documents
A new multifunctional hydroxytyrosol-fenofibrate with antidiabetic, antihyperlipidemic, antioxidant and antiinflammatory action
Xie, Yundong,Xu, Yanhong,Chen, Zizhang,Lu, Wenfang,Li, Na,Wang, Qiutang,Shao, Lihua,Li, Yiping,Yang, Guangde,Bian, Xiaoli
, p. 1749 - 1758 (2017)
Dyslipidemia, oxidative stress and inflammation are major risky factors involved in the pathophysiology of type 2 diabetes mellitus and atherosclerosis. Multifunctional intervene is more meaningful. The aim of this study was to evaluate the multifunctional effects of two new compounds, combination of fenofibric acid (FA) with tyrosol (T) or hydroxytyrosol (HT). Compared with fenofibrate (FF), FF-HT exhibited excellent antioxidant capacities in vitro and much improved hypolipidemia, reducing plasma triglyceride (TG), total cholesterol (TC), and malonaldehyde (MDA) by 76%, 54%, and 28%, while FF-T decreased the plasma parameters by 16%, 10%, and 20% in hyperlipidemic mice induced by Triton WR 1339. Furthermore, compound FF-HT exhibited significant antihyperglycemic, antihyperlipidemic, antioxidant and anti-inflammatory activities as well as attenuating hepatotoxicity in a type 2 diabetes experimental mouse model. The histological findings showed that FF-HT suppressed the development of hepatic lipid accumulation and ameliorated the damage in hepatic and pancreatic tissues compared to model mice. This study indicates for the first time that reasonable optimized drug design produce a compound entity which is conducive to the prevention of type 2 diabetes mellitus and its complications.
Preparation method of 2-(4-benzyloxyphenyl)ethanol
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, (2021/08/06)
The invention provides a preparation method of 2-(4-benzyloxyphenyl)ethanol. The preparation method comprises the following steps: 1) subjecting phenol to reacting with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound as shown in a formula II; 2) subjecting the compound as shown in the formula II to reacting with benzyl halide under an alkaline condition to obtain a compound as shown in a formula III, wherein the benzyl halide is one selected from benzyl bromide and benzyl chloride; 3) performing reduction treatment on the compound as shown in the formula III, and adjusting a reaction system to be an alkaline system to obtain a compound as shown in a formula IV; and 4) under the action of a catalyst, reducing the compound as shown in the formula IV under a hydrogen condition to obtain the 2-(4-benzyloxyphenyl)ethanol as shown in the formula I. The preparation method has the advantages of low cost, mild reaction conditions, safety in operation and less three-waste pollution, and is beneficial to being applied to industrial production.
1-(4-(2-cyclobutoxyethyl) phenoxy)-3-(isopropylamino) propyl-2-ol and preparation method thereof
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Paragraph 0007-0008; 0024-0026, (2020/10/14)
The invention belongs to the technical field of medicine preparation, and mainly relates to a new compound 1-(4-(2-cyclobutoxyethyl) phenoxy)-3-(isopropylamino) propyl-2-ol, a preparation method and application in detection of betaxolol hydrochloride and betaxolol hydrochloride eye drops related substances. The structure of the compound is as shown in the specification. The 1-(4-(2-cyclobutoxyethyl) phenoxy)-3-(isopropylamino) propyl-2-ol prepared by the preparation method disclosed by the invention can be used as a reference substance for detecting the content of 1-(4-(2-cyclobutoxyethyl) phenoxy)-3-(isopropylamino) propyl-2-ol in betaxolol hydrochloride and eye drops of betaxolol hydrochloride. Technical support and material guarantee are provided for improving the quality standard of betaxolol hydrochloride and eye drops thereof and controlling the safety of product quality, so that the national standard of betaxolol hydrochloride is at the world leading level, and the product has good economic benefits and social benefits.
