(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

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Chemical Name:(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid
CAS No.:1265322-68-6
Molecular Formula:C₂₆H₂₄F₃N₅O₄
Molecular Weight:527.503
Hs Code.:

Synonyms:(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

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Chemical Property of (S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

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Technology Process of (S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

There total 10 articles about (S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₈F₃N₅O₄

: 1265322-68-6
(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; In 1,3-dioxane; at 60 ℃;

Reference yield:

: 98534-81-7
1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

: 1265322-68-6
(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h

2.2: 60 °C

3.1: hydrogenchloride / 1,3-dioxane / 60 °C

With hydrogenchloride; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1,3-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 37675-18-6
(S)-(+)-nipecotic acid ethyl ester

: 1265322-68-6
(S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene

2.1: sodium tetrahydroborate / toluene; methanol / 1 h

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 85 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h

4.2: 60 °C

5.1: hydrogenchloride / 1,3-dioxane / 60 °C

With hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In 1,3-dioxane; methanol; isopropyl alcohol; toluene; acetonitrile;