Technology Process of (2'S,4'R)-(-)-5-chloro-3-ethyl-N-<(1-ethyl-4-tert-butyldimethylsilyloxy-2-pyrrolidinyl)methyl>-6-methoxysalicylamide
There total 6 articles about (2'S,4'R)-(-)-5-chloro-3-ethyl-N-<(1-ethyl-4-tert-butyldimethylsilyloxy-2-pyrrolidinyl)methyl>-6-methoxysalicylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 54 percent / triethylamine / dioxane; H2O / 120 h / Ambient temperature
2: 99 percent / imidazole / dimethylformamide / 72 h
3: 93 percent / KI, NH3 / methanol / 168 h / 40 °C
4: 82 percent / LiAlH4 / diethyl ether / 48 h / Heating
5: 1.) 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / 1.) CH2Cl2, a) -10 deg C, 100 min, b) RT, 30 min, 2.) CH2Cl2, RT, overnight
With
1H-imidazole; lithium aluminium tetrahydride; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide;
In
1,4-dioxane; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.3211
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / imidazole / dimethylformamide / 72 h
2: 93 percent / KI, NH3 / methanol / 168 h / 40 °C
3: 82 percent / LiAlH4 / diethyl ether / 48 h / Heating
4: 1.) 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / 1.) CH2Cl2, a) -10 deg C, 100 min, b) RT, 30 min, 2.) CH2Cl2, RT, overnight
With
1H-imidazole; lithium aluminium tetrahydride; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.3211
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 82 percent / LiAlH4 / diethyl ether / 48 h / Heating
2: 1.) 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / 1.) CH2Cl2, a) -10 deg C, 100 min, b) RT, 30 min, 2.) CH2Cl2, RT, overnight
With
lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
diethyl ether;
DOI:10.1248/cpb.39.3211
