(4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one

Base Information

• Chemical Name: (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one
• CAS No.: 473804-32-9
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.268
• Mol file: 473804-32-9.mol

Synonyms:(4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one

Chemical Property of (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one

There total 3 articles about (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,-dimethyl-1,3-dioxan-5-one (74181-34-3) + benzaldehyde (100-52-7) → (4S,1'S)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one + 4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one + (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one (473804-32-9)

Guidance literature:

With (2S,4R)-4-((tert-butyldiphenylsilyl)oxy)pyrrolidine-2-carboxylic acid; In water; at 20 ℃; for 18h; Title compound not separated from byproducts;

DOI:10.1002/anie.200502488

Reference yield:

2,2,-dimethyl-1,3-dioxan-5-one (74181-34-3) + benzaldehyde (100-52-7) → (R)-4-((S)-Hydroxy-phenyl-methyl)-2,2-dimethyl-[1,3]dioxan-5-one + (1'R,4S)-4-(1'-hydroxy-1'-phenyl)methyl-2,2-dimethyl-[1,3]dioxan-5-one + (4S,1'S)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one + (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one (473804-32-9)

Guidance literature:

2,2,-dimethyl-1,3-dioxan-5-one; With L-proline; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzaldehyde; In N,N-dimethyl-formamide; at 2 ℃; Title compound not separated from byproducts;

DOI:10.1016/j.tet.2005.09.060

Reference yield:

2,2,-dimethyl-1,3-dioxan-5-one (74181-34-3) + benzaldehyde (100-52-7) → C13H16O4 + (4S,1'S)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one + (4R,1'R)-4-(hydroxy-phenyl-methyl)-2,2-dimethyl-1,3-dioxan-5-one (473804-32-9)

Guidance literature:

With L-proline; lithium chloride; In dimethyl sulfoxide; at 5 ℃; for 168h; Further Variations:; Reagents; time; Product distribution;

DOI:10.1055/s-2006-950421

upstream raw materials:

2,2,-dimethyl-1,3-dioxan-5-one

benzaldehyde