3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

Base Information

Chemical Name:3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester
CAS No.:129833-16-5
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

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Chemical Property of 3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

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Technology Process of 3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

There total 4 articles about 3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3-(2,5-Dimethoxy-3,6-dimethyl-4-pyridin-3-ylmethyl-phenyl)-propionic acid ethyl ester

: 129833-16-5
3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 ℃; for 1h;
DOI:10.1021/jm00105a042

Reference yield:

: 129813-52-1
3-(2,5-dimethoxy-3,6-dimethylbenzyl)pyridine

: 129833-16-5
3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / TiCl₄ / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) NaH (60percent dispersion in mineral oil) / 1.) DMF, 0 deg C, 20 min, 2.) RT, 1 h

3: H₂ / 5percent Pd/C / acetic acid / 80 °C

4: 81 percent / cerium ammonium nitrate (CAN) / H₂O; acetonitrile / 1 h / 0 °C

With ammonium cerium(IV) nitrate; hydrogen; titanium tetrachloride; sodium hydride; palladium on activated charcoal; In dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1021/jm00105a042

Reference yield:

: 129813-53-2
3-(4-formyl-2,5-dimethoxy-3,6-dimethylbenzyl)pyridine

: 129833-16-5
3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyclohexa-1,4-dienyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH (60percent dispersion in mineral oil) / 1.) DMF, 0 deg C, 20 min, 2.) RT, 1 h

2: H₂ / 5percent Pd/C / acetic acid / 80 °C

3: 81 percent / cerium ammonium nitrate (CAN) / H₂O; acetonitrile / 1 h / 0 °C

With ammonium cerium(IV) nitrate; hydrogen; sodium hydride; palladium on activated charcoal; In water; acetic acid; acetonitrile;
DOI:10.1021/jm00105a042