2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

Base Information

Chemical Name:2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol
CAS No.:1329997-22-9
Molecular Formula:C₂₀H₃₄O₃Si
Molecular Weight:350.574
Hs Code.:

Synonyms:2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

Suppliers and Price of 2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

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Technology Process of 2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

There total 4 articles about 2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1329997-21-8
2-benzyloxy-1-[(hydroxymethyl)cyclobutyl]ethan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1329997-22-9
2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100053

Reference yield:

: 1329997-20-7
ethyl 1-(2-(benzyloxy)acetyl)cyclobutanecarboxylate

: 1329997-22-9
2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux; Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100053

Reference yield:

: 19810-31-2
Benzyloxyacetyl chloride

: 1329997-22-9
2-benzyloxy-1-[1-(tert-butyldimethysilyl)oxy(methyl)cyclobutyl]ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: 0.67 h / -78 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux; Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; 1.1: Claisen condensation / 1.2: Claisen condensation;
DOI:10.1002/ejoc.201100053