C₂₇H₃₃FN₄O₂

Base Information

Chemical Name:C₂₇H₃₃FN₄O₂
CAS No.:1186046-72-9
Molecular Formula:C₂₇H₃₃FN₄O₂
Molecular Weight:464.583
Hs Code.:

C<sub>27</sub>H<sub>33</sub>FN<sub>4</sub>O<sub>2</sub>

Synonyms:C₂₇H₃₃FN₄O₂

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Chemical Property of C₂₇H₃₃FN₄O₂

Chemical Property:

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Technology Process of C₂₇H₃₃FN₄O₂

There total 7 articles about C₂₇H₃₃FN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₇FN₄O₂

: 1186046-72-9
C₂₇H₃₃FN₄O₂

Guidance literature:: With hydrogen; trifluoroacetic acid; 10 wt% Pd(OH)2 on carbon; In methanol; under 3102.97 Torr; Inert atmosphere;

Reference yield:

: 1119-46-6
5-chloro-valeric acid

: 1186046-72-9
C₂₇H₃₃FN₄O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 - -20 °C

3.2: 0.5 h / -78 °C

4.1: Burgess Reagent / tetrahydrofuran / 6 h / Reflux

5.1: trifluoroacetic acid / tetrahydrofuran / 24 h / Reflux

6.1: hydrogen; trifluoroacetic acid / 10 wt% Pd(OH)2 on carbon / methanol / 3102.97 Torr / Inert atmosphere

With Burgess Reagent; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; n-heptane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 19347-73-0
6-chlorohexanoyl chloride

: 1186046-72-9
C₂₇H₃₃FN₄O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 1 h / -78 - -20 °C

3.2: 0.5 h / -78 °C

4.1: Burgess Reagent / tetrahydrofuran / 6 h / Reflux

5.1: trifluoroacetic acid / tetrahydrofuran / 24 h / Reflux

6.1: hydrogen; trifluoroacetic acid / 10 wt% Pd(OH)2 on carbon / methanol / 3102.97 Torr / Inert atmosphere

With pyridine; Burgess Reagent; hydrogen; sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; n-heptane; dichloromethane; N,N-dimethyl-formamide; mineral oil;