ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

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Chemical Name:ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate
CAS No.:1362861-18-4
Molecular Formula:C₃₀H₃₃NO₇
Molecular Weight:519.595
Hs Code.:

Synonyms:ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

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Chemical Property of ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

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Technology Process of ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

There total 2 articles about ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 875654-34-5
4-isopropoxy-5-methoxy-2-methoxymethoxyphenylboronic acid

: 167631-20-1
5-benzyloxy-3-iodo-1H-indole-2-carboxylic acid ethyl ester

: 1362861-18-4
ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; toluene; for 7h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2012.01.040

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1362861-18-4
ethyl 5-(benzyloxy)-3-[4-isopropoxy-5-methoxy-2-(methoxymethoxy) phenyl]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 7 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium hydrogencarbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2012.01.040