[5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid

Base Information

Chemical Name:[5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid
CAS No.:875654-34-5
Molecular Formula:C12H19BO6
Molecular Weight:270.09
Hs Code.:
DSSTox Substance ID:DTXSID701157572
Nikkaji Number:J2.275.771G

Synonyms:875654-34-5;DTXSID701157572;(4-Isopropoxy-5-methoxy-2-(methoxymethoxy)phenyl)boronic acid;B-[5-Methoxy-2-(methoxymethoxy)-4-(1-methylethoxy)phenyl]boronic acid

Suppliers and Price of [5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of [5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:270.1274685
Heavy Atom Count:19
Complexity:250

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:B(C1=CC(=C(C=C1OCOC)OC(C)C)OC)(O)O

Technology Process of [5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid

There total 3 articles about [5-Methoxy-2-(methoxymethoxy)-4-propan-2-yloxyphenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875654-37-8
2-isopropoxy-1-methoxy-4-methoxymethoxybenzene

: 875654-34-5
4-isopropoxy-5-methoxy-2-methoxymethoxyphenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / N-bromosuccinimide / dimethylformamide / 0.5 h / 0 °C

2.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 87 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

With N-Bromosuccinimide; tert.-butyl lithium; In tetrahydrofuran; N,N-dimethyl-formamide; pentane;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 875654-34-5
4-isopropoxy-5-methoxy-2-methoxymethoxyphenylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: m-chloroperbenzoic acid / CH₂Cl₂; H₂O / 3 h / 0 °C

1.2: 86 percent / potassium carbonate / methanol / 1 h / 20 °C

2.1: 68 percent / sodium hydride / tetrahydrofuran; hexane / 0 - 20 °C

3.1: 98 percent / N-bromosuccinimide / dimethylformamide / 0.5 h / 0 °C

4.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

4.2: 87 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

With N-Bromosuccinimide; tert.-butyl lithium; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; pentane; 1.1: Baeyer-Villiger oxidation;
DOI:10.1016/j.tet.2005.10.014

Reference yield:

: 86636-00-2
3-isopropoxy-4-methoxyphenol

: 875654-34-5
4-isopropoxy-5-methoxy-2-methoxymethoxyphenylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 68 percent / sodium hydride / tetrahydrofuran; hexane / 0 - 20 °C

2.1: 98 percent / N-bromosuccinimide / dimethylformamide / 0.5 h / 0 °C

3.1: tert-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 87 percent / trimethyl borate / tetrahydrofuran; pentane / -78 - 20 °C

With N-Bromosuccinimide; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; pentane;
DOI:10.1016/j.tet.2005.10.014