(1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate

Base Information

• Chemical Name: (1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate
• CAS No.: 1248343-26-1
• Molecular Formula: C₂₃H₂₁NO₅
• Molecular Weight: 391.423

Synonyms:(1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate

Chemical Property of (1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate

There total 5 articles about (1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzoyl-2-tert-butyldimethylsilyllycorine (1210819-55-8) → (1S,2S,3a(1)S,12bS)-2-hydroxy-2,3a(1),4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate (1248343-26-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.06.130

Reference yield: 33.0%

(1S,2S,3a(1)S,12bS)-1-hydroxy-2,3a(1),4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1,2-diyl dibenzoate (1350717-32-6) → (1S,2S,3a(1)S,12bS)-2-hydroxy-2,3a(1),4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate (1248343-26-1) + (1S,2S,3a(1)S,12bS)-1-hydroxy-2,3a(1),4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-2-yl benzoate (1350717-33-7)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.bmc.2011.09.051

Reference yield:

(1S,2S,3a1S,12bS)-2-((tert-butyldimethylsilyl)oxy)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-ol (1108137-69-4) + benzoic acid (65-85-0,8013-63-6) → (1S,2S,3a(1)S,12bS)-2-hydroxy-2,3a(1),4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate (1248343-26-1)

Guidance literature:

(1S,2S,3a¹S,12bS)-2-((tert-butyldimethylsilyl)oxy)-2,3a¹,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-ol; benzoic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1080/10286020.2020.1844674

upstream raw materials:

1-benzoyl-2-tert-butyldimethylsilyllycorine

(1S,2S,3a⁽¹⁾S,12bS)-1-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1,2-diyl dibenzoate

benzoyl chloride

lycorine

Downstream raw materials:

1-O-benzoyl-2-O-acetyllycorine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1248343-26-1 (1S,2S,3a⁽¹⁾S,12bS)-2-hydroxy-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl benzoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send