8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Base Information

Chemical Name:8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide
CAS No.:1197856-34-0
Molecular Formula:C₂₆H₁₉F₃N₂O₅S
Molecular Weight:528.508
Hs Code.:

Synonyms:8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Suppliers and Price of 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

There total 10 articles about 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1197856-25-9
methyl 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

: 1197856-34-0
8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: methyl 8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 100 ℃; for 38h; Inert atmosphere; Microwave irradiation;

In methanol; for 0.0833333h; Inert atmosphere;
DOI:10.1021/ol9023024

Reference yield:

: 1197856-33-9
2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

: 1197856-34-0
8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: With trifluoroacetic acid; In water; at 80 ℃; for 0.25h;

Reference yield:

: 1024869-14-4
C₁₁H₁₂F₃NO

: 1197856-34-0
8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 16 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium methylate / methanol / 16 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: trifluoroacetic acid / water / 0.17 h / 80 °C / Microwave irradiation

6.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 0 - 20 °C

With water; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;