2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Base Information

Chemical Name:2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide
CAS No.:1197856-33-9
Molecular Formula:C₃₄H₂₇F₃N₂O₆S
Molecular Weight:648.659
Hs Code.:

2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Synonyms:2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

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Chemical Property of 2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

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Technology Process of 2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

There total 8 articles about 2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1197856-24-8
methyl 2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide

: 1197856-33-9
2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: methyl 2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylate 1,1-dioxide; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 100 ℃; for 55h; Inert atmosphere; Microwave irradiation;

In methanol; for 0.0833333h; Inert atmosphere;
DOI:10.1021/ol9023024

Reference yield:

: 1024869-14-4
C₁₁H₁₂F₃NO

: 1197856-33-9
2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 16 h / 0 - 20 °C

2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 16 h / 120 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium methylate / methanol / 16 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 0 - 20 °C

With water; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1197856-33-9
2-(4-methoxybenzyl)-8-(naphthalen-1-ylmethyl)-6-oxo-9-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H,6H-pyrido[1,2-e][1,2,5]thiadiazine-4-carboxylic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 20 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 16 h / 0 - 20 °C

3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 16 h / 120 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

5.1: sodium methylate / methanol / 16 h / 0 - 20 °C

5.2: 1 h / 0 - 20 °C

6.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 0 - 20 °C

With hydrogenchloride; water; sodium methylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;