3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea

Base Information

• Chemical Name: 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea
• CAS No.: 342884-10-0
• Molecular Formula: C₂₁H₂₄ClN₃O₃S
• Molecular Weight: 433.959

Synonyms:3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea

Chemical Property of 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea

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Technology Process of 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea

There total 3 articles about 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 2-amino-3-(2-chlorobenzoyl)-6-acetyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (130312-24-2) + diethylamine (109-89-7) → 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea (342884-10-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(02)00228-7

Reference yield:

1-acetyl-4-piperidinone (32161-06-1) → 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea (342884-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: S; Et₃N / dimethylformamide / Heating

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

With sulfur; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Gewald synthesis;

DOI:10.1016/S0960-894X(02)00228-7

Reference yield:

2-Chlorobenzoyl acetonitrile (40018-25-5) → 3-[6-acetyl-3-(2-chloro-benzoyl)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl]-1,1-diethyl-urea (342884-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: S; Et₃N / dimethylformamide / Heating

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

With sulfur; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Gewald synthesis;

DOI:10.1016/S0960-894X(02)00228-7

upstream raw materials:

bis(trichloromethyl) carbonate

2-amino-3-(2-chlorobenzoyl)-6-acetyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

diethylamine

1-acetyl-4-piperidinone

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