Technology Process of methyl 2-{[2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enyl][(4-nitrophenyl)sulfonyl]amino}pent-4-enoate
There total 2 articles about methyl 2-{[2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enyl][(4-nitrophenyl)sulfonyl]amino}pent-4-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(4-nitrobenzenesulfonylamino)pent-4-enoic acid methyl ester; 5-iodo-1,3-dimethyluracil;
With
tetraethylammonium chloride; potassium carbonate; triphenylphosphine;
palladium diacetate;
In
toluene;
cooling;
1,2-propanediene;
In
toluene;
at 80 ℃;
for 46h;
DOI:10.1016/j.tet.2005.08.078
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 0 - 20 °C
1.2: 55 percent / triethylamine / CH2Cl2 / 16 h / 0 - 20 °C
2.1: potassium carbonate; tetraethylammonium chloride; triphenylphosphine / palladium(II) acetate / toluene / cooling
2.2: 67 percent / toluene / 46 h / 80 °C
With
thionyl chloride; tetraethylammonium chloride; potassium carbonate; triphenylphosphine;
palladium diacetate;
In
toluene;
DOI:10.1016/j.tet.2005.08.078
