2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

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Chemical Name:2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide
CAS No.:155512-51-9
Molecular Formula:C₂₁H₂₃Cl₂N₃O₃
Molecular Weight:436.338
Hs Code.:

Synonyms:2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

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Chemical Property of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

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Technology Process of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

There total 4 articles about 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: (S)-1-<2-(methylamino)-2-(3-nitrophenyl)ethyl>pyrrolidine

: 155512-51-9
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 17h;

Reference yield:

: 116508-51-1
(1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine

: 6831-55-6
2-(3,4-dichlorophenyl)acetyl chloride

: 155512-51-9
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

Guidance literature:: With sulfuric acid; nitric acid; Multistep reaction; 1.) 0 deg C;
DOI:10.1021/jm00037a001

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 155512-51-9
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-nitrophenyl)-2-(pyrrolidin-1-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2.5 h / 76 °C

2: 1.) conc. H₂SO₄, conc. HNO₃, 2.) Et₃N / 1.) 45 min, 2.) CH₂Cl₂, 25 deg C, 21 h

With thionyl chloride; sulfuric acid; nitric acid; triethylamine;
DOI:10.1021/jm00052a008