((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Base Information

Chemical Name:((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol
CAS No.:186540-95-4
Molecular Formula:C₁₄H₁₇ClN₄O₃
Molecular Weight:324.767
Hs Code.:

Synonyms:((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of ((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

There total 1 articles about ((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 186540-95-4
((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / acetone / 20 °C

2: triethylamine / tert-butyl alcohol / 100 °C

3: 1H-imidazole / dichloromethane / 20 °C

4: 110 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; acetone; tert-butyl alcohol;

Reference yield:

: 186540-95-4
((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 1380350-33-3
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 18.5 h

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16.5 h / 80 °C

3.1: trimethylphosphane / tetrahydrofuran / 2 h / 0 °C

3.2: 2.75 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; methanol / acetic acid / 1,2-dichloro-ethane / 20 °C

With methanol; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trimethylphosphane; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; butan-1-ol;

Reference yield:

: 186540-95-4
((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 1380350-34-4
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 18.5 h

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16.5 h / 80 °C

3.1: trimethylphosphane / tetrahydrofuran / 2 h / 0 °C

3.2: 2.75 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; methanol / acetic acid / 1,2-dichloro-ethane / 20 °C

5.1: triethylamine / acetonitrile / 20 h / 80 °C

With methanol; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; butan-1-ol;