ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Base Information

Chemical Name:ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate
CAS No.:1380350-34-4
Molecular Formula:C₃₅H₅₀N₆O₆
Molecular Weight:650.819
Hs Code.:

ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Synonyms:ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

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Chemical Property of ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

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Technology Process of ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

There total 10 articles about ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 75-30-9
2-iodo-propane

: 1380350-33-3
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

: 1380350-34-4
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃; for 20h;

Reference yield:

: 186540-95-4
((3aR,4R,6R,6aS)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 1380350-34-4
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 18.5 h

2.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16.5 h / 80 °C

3.1: trimethylphosphane / tetrahydrofuran / 2 h / 0 °C

3.2: 2.75 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; methanol / acetic acid / 1,2-dichloro-ethane / 20 °C

5.1: triethylamine / acetonitrile / 20 h / 80 °C

With methanol; di-isopropyl azodicarboxylate; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; trimethylphosphane; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; butan-1-ol;

Reference yield:

: 1968-40-7
ethyl 4-pentenoate

: 1380350-34-4
ethyl 3-(3-((((3aR,4R,6R,6aS)-6-(6-((2,4-dimethoxybenzyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: zinc/copper couple / diethyl ether / 72 h / 20 °C

2: zinc; ammonium chloride / methanol / 3 h / Reflux

3: sodium tris(acetoxy)borohydride; methanol / acetic acid / 1,2-dichloro-ethane / 20 °C

4: triethylamine / acetonitrile / 20 h / 80 °C

With methanol; zinc/copper couple; sodium tris(acetoxy)borohydride; ammonium chloride; triethylamine; zinc; acetic acid; In methanol; diethyl ether; 1,2-dichloro-ethane; acetonitrile;