Technology Process of (Z)-4-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid
There total 11 articles about (Z)-4-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3-amino-2-hydroxyphenyl)furan-2-carboxylic acid hydrobromide;
With
hydrogenchloride; sodium nitrite;
In
water;
for 0.333333h;
Cooling with ice;
5-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,4-dihydropyrazol-3-one;
With
sodium hydrogencarbonate;
In
ethanol; water;
at 20 ℃;
for 24h;
pH=8 - 9;
With
hydrogenchloride;
In
water;
pH=2 - 3;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C
2.1: potassium carbonate / acetone / 40 h / 70 °C
3.1: potassium acetate / tetrakis(triphenylphosphine) palladium(0) / etheroxalic acid dimethyl ether / 17 h / Reflux
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
4.2: pH 3
5.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3 h / Reflux
6.1: boron tribromide / dichloromethane / 4.5 h / 20 °C
7.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice
7.2: 24 h / 20 °C / pH 8 - 9
7.3: pH 2 - 3 / Cooling with ice
With
hydrogenchloride; sodium nitrate; sulfuric acid; ammonium formate; potassium acetate; boron tribromide; potassium carbonate; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonium hydroxide; zinc; water / 6 h / 20 °C
1.2: pH 3
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / Reflux
2.2: pH 3
3.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3 h / Reflux
4.1: boron tribromide / dichloromethane / 4.5 h / 20 °C
5.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice
5.2: 24 h / 20 °C / pH 8 - 9
5.3: pH 2 - 3 / Cooling with ice
With
hydrogenchloride; ammonium hydroxide; water; ammonium formate; boron tribromide; potassium carbonate; zinc; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; dichloromethane; water; ethyl acetate;
