2434-03-9

Usage

Uses

Used in Chemical Synthesis:
2,3-Dibromofuran-5-carboxylic acid is used as a key intermediate in the synthesis of complex organic molecules, particularly for those involving the intramolecular Diels-Alder reaction. Its unique structural features, including the bromine substituents, play a crucial role in enhancing the yield of the cycloaddition reactions.
Used in Pharmaceutical Research:
In the field of pharmaceutical research, 2,3-Dibromofuran-5-carboxylic acid is utilized as a building block for the development of novel drug candidates. The compound's reactivity and structural properties make it a valuable component in the design and synthesis of potential therapeutic agents.
Used in Material Science:
2,3-Dibromofuran-5-carboxylic acid is also employed in material science for the development of new polymers and other advanced materials. Its ability to participate in various chemical reactions allows for the creation of materials with unique properties and potential applications in various industries.

InChI:InChI=1/C5H2Br2O3/c6-2-1-3(5(8)9)10-4(2)7/h1H,(H,8,9)

Upstream product

• 611-13-2 2-furoic acid methyl ester 
• 88-14-2 2-furanoic acid 
• 54113-41-6 methyl 4,5-dibromofuran-2-carboxylate 
• 2433-85-4 4,5-dibromo-2-furancarboxaldehyde 
• 98-01-1 furfural 

Downstream Products

• 30544-34-4 2,3-dibromofuran 
• 54113-42-7 2,3-dibromo-5-(ethoxycarbonyl)furan 
• 76311-89-2 3-bromo-2,5-dihydrofuran-2-one 
• 906344-89-6 4,5-dibromofuran-2-carboxylic acid benzylamide 
• 3439-02-9 4-bromofuran-2-carboxylic acid 
• 1310848-83-9 (4,5-dibromofuran-2-yl)(3,4-dihydroxyphenyl)methanone 
• 1310848-81-7 (4,5-dibromofuran-2-yl)(3-hydroxy-4-methoxyphenyl)methanone 
• 1443757-84-3 [1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-[4-(4,5-dibromo-furan-2-carbonyl)-3-methyl-piperazin-1-yl]-methanone 
• 1047628-48-7 N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide 
• 1047627-32-6 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-4-(1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide 
• 1443758-31-3 (S)-[4-(4,5-dibromo-furan-2-carbonyl)-3-methyl-piperazin-1-yl]-[1-(3-fluoro-phenyl)-1H-[1,2,4]triazol-3-yl]-methanone 
• 1443758-30-2 (S)-[4-(4,5-dibromo-furan-2-carbonyl)-3-methyl-piperazin-1-yl]-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone 
• 1257792-60-1 (Z)-4-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid 
• 1257792-76-9 4-(3-amino-2-hydroxyphenyl)furan-2-carboxylic acid hydrobromide 

Relevant academic research and scientific papers

SYNTHESIS OF SOME FURYL- AND THIENYLACRYLATES OR DIACRYLATES AND ACRYLIC ACIDS BY THE PALLADIUM CATALYSED VINYLATION OF SUBSTITUTED BROMOFURANS AND BROMOTHIOPHENES

Furyl- and thienylacrylates (8-14) and acrylic acids (8a,10a-14a) are prepared in moderate yields by palladium catalysed coupling of substituted bromofurans and bromothiophenes with ethyl acrylate.

Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR

Certain oxo-dihydroisoindote sulfonamide compounds of Formula (I): wherein R1 and R2 are each independently fluoro or chloro; R3 is H or methyl; R4 is chloro or bromo; one of X and Y is a carbonyl and the other

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

The preparation of 2,3,5-tri- and 2,3-disubstituted furans by regioselective palladium(0)-catalyzed coupling reactions: Application to the syntheses of rosefuran and the F5 furan fatty acid

The 5-acceptor-substituted 2,3-dibromofurans 1 and 2 underwent a regioselective Pd0-catalyzed coupling reaction at the C-2 carbon atom. With alkynes the corresponding 2-alkynylfurans 4 and 5 were accessible (49-97% yield) Alkyl-, aryl-, and alk

Synthesis of furan and thiophene analogs of duocarmycin SA

Total synthesis of furan and thiophene analogs 6 and 7 of duocarmycin SA was achieved in racemic forms, starting from methyl 4,5-dibromo-2-furan- and thiophenecarboxylates (15a and 15b). Lithio derivatives 12a (a series: X = O) and 12b (b series: X = S) were reacted with the aldehyde 22 for preparation of 25a and 25b, and successive synthetic operations, including Heck reaction of 25a and 25b to obtain 26a+27a and 26b+27b, and B ring aromatization, 28a and 28b→31a and 31b, based on our previous total synthesis of duocarmycin SA, afforded 36a and 36b. Treatment of 36a and 36b with potassium carbonate in methanol directly afforded cyclopropapyrroloindole derivatives 38a and 38b, whose condensation with the 5,6,7-trimethoxy-2-indolecarbonyl unit completed the synthesis of (±)-6 and (±)-7.

Two Syntheses of Manoalide via Heteroatom-Assisted Alkyne Carbometallation

Two approaches to the sesterterpenoid phospholipase A2 inhibitors seco-manoalide (3) and manoalide (1) are described based on carbometallation of propargylic alcohols to generate the functionalised C6-C7 trisubstituted alkene.Both syntheses also deploy the photooxidation of a furan in order to generate a 4-substituted 5-hydroxy-2(5H)-furanone moiety.