2434-03-9Relevant articles and documents
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Gol'dfarb,Tarasowa
, (1960)
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Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives
Zheng, Fei Lang,Ban, Shu Rong,Feng, Xiu E,Zhao, Cheng Xiao,Lin, Wenhan,Li, Qing Shan
experimental part, p. 4897 - 4911 (2011/08/10)
A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.
SULFONAMIDE COMPOUNDS
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Page/Page column 25, (2010/10/20)
Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.
Synthesis of furan and thiophene analogs of duocarmycin SA
Muratake, Hideaki,Okabe, Kazuaki,Takahashi, Michiko,Tonegawa, Miyuki,Natsume, Mitsutaka
, p. 799 - 806 (2007/10/03)
Total synthesis of furan and thiophene analogs 6 and 7 of duocarmycin SA was achieved in racemic forms, starting from methyl 4,5-dibromo-2-furan- and thiophenecarboxylates (15a and 15b). Lithio derivatives 12a (a series: X = O) and 12b (b series: X = S) were reacted with the aldehyde 22 for preparation of 25a and 25b, and successive synthetic operations, including Heck reaction of 25a and 25b to obtain 26a+27a and 26b+27b, and B ring aromatization, 28a and 28b→31a and 31b, based on our previous total synthesis of duocarmycin SA, afforded 36a and 36b. Treatment of 36a and 36b with potassium carbonate in methanol directly afforded cyclopropapyrroloindole derivatives 38a and 38b, whose condensation with the 5,6,7-trimethoxy-2-indolecarbonyl unit completed the synthesis of (±)-6 and (±)-7.