(5-Methylpyrimidin-4-yl)methanamine

Base Information

• Chemical Name: (5-Methylpyrimidin-4-yl)methanamine
• CAS No.: 75985-23-8
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID80607894
• Wikidata: Q82506989
• Mol file: 75985-23-8.mol

Synonyms:(5-methylpyrimidin-4-yl)methanamine;75985-23-8;5-METHYL-4-PYRIMIDINEMETHANAMINE;4-Pyrimidinemethanamine,5-methyl-;SCHEMBL2887918;DTXSID80607894;AKOS006351982;1-(5-Methylpyrimidin-4-yl)methanamine;SB18556;DB-075043;CS-0455442;F1967-2332

Chemical Property of (5-Methylpyrimidin-4-yl)methanamine

Chemical Property:

• PSA: 51.80000
• LogP: 0.94400
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-4-pyrimidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=CN=C1CN
• Uses: An intermediate in the preparation of pyridazinone derivatives as P2X7 receptor inhibitors An intermediate in the preparation of pyridazinone derivatives as P2X7 receptor inhibitors use in the treatment of rheumatoid arthritis.

Technology Process of (5-Methylpyrimidin-4-yl)methanamine

There total 5 articles about (5-Methylpyrimidin-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ (5-methylpyrimidin-4-yl)methanamine (75985-23-8)

Guidance literature:

Reference yield:

2-((5-methylpyrimidin-4-yl)methyl)isoindoline-1,3-dione (1149586-13-9) → (5-methylpyrimidin-4-yl)methanamine (75985-23-8)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 12h;

Reference yield:

4,5-dimethylpyrimidine (694-81-5) → (5-methylpyrimidin-4-yl)methanamine (75985-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid / 2 h / 50 °C / Sealed tube

2: N,N-dimethyl-formamide / 2 h / 80 °C

3: hydrazine hydrate / methanol / 12 h / 20 °C

With bromine; hydrazine hydrate; acetic acid; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

4,5-dimethylpyrimidine

4-(Bromomethyl)-5-methylpyrimidine

2-((5-methylpyrimidin-4-yl)methyl)isoindoline-1,3-dione

5-methylpyrimidine

Refernces

• 1、 -. "PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS". Page/Page column 170. . Retrieved 2009/06/27.