694-81-5

Upstream product

• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 77287-34-4 formamide 
• 77-78-1 dimethyl sulfate 
• 78-93-3 butanone 
• 2036-41-1 5-methylpyrimidine 
• 917-54-4 methyllithium 
• 7732-18-5 water 
• 290-87-9 1,3,5-Triazine 
• 5910-89-4 2,3-dimethylpyrazine 
• 14331-54-5 2,4-dimethylpyrimidine 
• 108-50-9 2,6-dimethylpyrazine 

Downstream Products

• 114969-53-8 4,5-Dimethyl-pyrimidine 1-oxide 
• 114969-97-0 Picric acid; compound with 4,5-dimethyl-pyrimidine 3-oxide 
• 114969-77-6 4,5-Dimethyl-pyrimidine-2-carbonitrile 
• 114969-82-3 5,6-Dimethyl-pyrimidine-4-carbonitrile 
• 75985-23-8 (5-methylpyrimidin-4-yl)methanamine 

Relevant academic research and scientific papers

Vapor phase phototransposition chemistry of dimethylpyrazines and dimethylpyrimidines

Based on their phototransposition chemistry, the three dimethylpyrazines and four dimethylpyrimidines can be arranged into two groups. 2,5-Dimethylpyrazine, 2,5-dimethylpyrimidine, and 4,6-dimethylpyrimidine constitute a photochemical triad. Irradiation of any one member of the triad in the vapor phase results in the formation of the other two members. The other four isomers, 2,6-dimethylpyrazine, 2,3-dimethylpyrazine, 2,4- dimethylpyrimidine, and 4,5-dimethylpyrimidine constitute a photochemical tetrad. Irradiation of any one member results in the formation of the other three. In addition, 2,4-dimethylpyrimidine and 2,6-dimethylpyrazine also photoisomerize to 3,6-dimethylpyridazine. Irradiation of the last in the vapor state resulted in the four members of the tetrad.

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Direct access to pyrimidines through organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine

An organocatalytic inverse-electron-demand Diels-Alder reaction of ketones with 1,3,5-triazine through enamine catalysis has been developed. This method could furnish 4,5-disubstituted pyrimidines in good yields and high levels of regioselectivities.

Highly Regioselective Bromination Reactions of Polymethylpyrimidines

4,5-Dimethyl- and 4,5,6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl4 and at C4(6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield.The remaining methyl group(s) can also be brominated with high regioselectivity.The 2-methylthio substituent is not oxidized under these conditions.