N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

Base Information

Chemical Name:N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine
CAS No.:135227-45-1
Molecular Formula:C₃₃H₃₉F₃N₂O₆
Molecular Weight:616.678
Hs Code.:

Synonyms:N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

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Technology Process of N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

There total 4 articles about N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 135227-38-2
N'-(tert-Butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

: 135227-45-1
N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

Guidance literature:: With triethylamine; In tetrachloromethane; for 24h;
DOI:10.1021/jo00019a017

Reference yield:

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: 135227-45-1
N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, room temperature, 15 min, 2.) 0 deg C to room temperature, several h

2: 1.) NaH / 1.) DMF, room temperature, 1 h, 2.) 70-80 deg C, 18 h

3: 85 percent / K₂CO₃, H₂O / methanol / 1.5 h / Heating

4: 70 percent / triethylamine / CCl₄ / 24 h

With water; sodium hydride; potassium carbonate; triethylamine; In methanol; tetrachloromethane;
DOI:10.1021/jo00019a017

Reference yield:

: 135227-37-1
N-(Trifluoroacetyl)-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

: 135227-45-1
N-<(R)-α-Methoxy-α-(trifluoromethyl)phenylacetyl>-N'-(tert-butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃, H₂O / methanol / 1.5 h / Heating

2: 70 percent / triethylamine / CCl₄ / 24 h

With water; potassium carbonate; triethylamine; In methanol; tetrachloromethane;
DOI:10.1021/jo00019a017