N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

Base Information

Chemical Name:N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine
CAS No.:349609-17-2
Molecular Formula:C₂₂H₃₀N₂O₆
Molecular Weight:418.49
Hs Code.:

Synonyms:N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

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Chemical Property of N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

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Technology Process of N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

There total 6 articles about N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 349609-05-8
1-[1-amino-2-(phenylmethoxy)ethyl]-2-methoxy-3-nitro-benzene

: 349609-17-2
N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

Guidance literature:: With potassium carbonate; In acetonitrile; Heating;
DOI:10.1002/1521-3773(20010417)40:8<1463::AID-ANIE1463>3.0.CO;2-8

Reference yield:

: 62717-78-6,141303-38-0
2-(2-methoxyphenyl)oxirane

: 349609-17-2
N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaN₃ / acetone / 3 h / Heating

2.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

2.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

3.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

4.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

5.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

6.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

With lithium hydroxide; sodium azide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/ja0174027

Reference yield:

: 2-azido-2-(2-methoxy-phenyl)-ethanol

: 349609-17-2
N-(2,2-diethoxyethyl)-2-methoxy-3-nitro-α-[(phenylmethoxy)methyl]-benzenemetamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran; various solvent(s) / 0.25 h / 20 °C

1.2: 13.18 g / KI / tetrahydrofuran; various solvent(s) / 2 h

2.1: 87 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

3.1: KNO₃ / CH₂Cl₂ / 48 h / -20 °C

4.1: 10.5 g / aq. LiOH / tetrahydrofuran; ethanol / 14 h

5.1: 74 percent / K₂CO₃ / acetonitrile / 120 h / Heating

With lithium hydroxide; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ja0174027