5-(2-bromophenyl)-3-phenyl-1H-pyrazole

Base Information

• Chemical Name: 5-(2-bromophenyl)-3-phenyl-1H-pyrazole
• CAS No.: 1387637-91-3
• Molecular Formula: C₁₅H₁₁BrN₂
• Molecular Weight: 299.17
• Mol file: 1387637-91-3.mol

Synonyms:5-(2-bromophenyl)-3-phenyl-1H-pyrazole

Chemical Property of 5-(2-bromophenyl)-3-phenyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(2-bromophenyl)-3-phenyl-1H-pyrazole

There total 11 articles about 5-(2-bromophenyl)-3-phenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-bromochalcone → 3-(2-bromophenyl)-5-phenyl-1H-pyrazole (1387637-91-3)

Guidance literature:

With iodine; potassium carbonate; toluene-4-sulfonic acid hydrazide; In ethanol; at 75 ℃; for 2h; regioselective reaction; Green chemistry;

DOI:10.1016/j.tetlet.2016.05.020

Reference yield: 81.0%

(2-nitroethenyl)benzene (102-96-5) + N’-(2-bromobenzylidene)-4-methylbenzenesulfonohydrazide (158918-49-1) → 5-(2-bromophenyl)-3-phenyl-1H-pyrazole (1387637-91-3) + 5-(o-bromophenyl)-4-phenyl-1H-pyrazole (1454253-91-8)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; In tetrahydrofuran; for 4h; regioselective reaction; Reflux;

DOI:10.1039/c3ob41435c

Reference yield: 79.0%

1-(2'-bromophenyl)-3-phenylpropane-1,3-dione (36081-80-8) → 5-(2-bromophenyl)-3-phenyl-1H-pyrazole (1387637-91-3)

Guidance literature:

With hydrazine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

upstream raw materials:

phenylacetylene

N’-(2-bromobenzylidene)-4-methylbenzenesulfonohydrazide

ortho-bromobenzaldehyde

(1-phenylethylidene)hydrazine

Downstream raw materials:

2,5-diphenyl-pyrazolo[5,1-a]isoquinoline

2-phenyl-5-p-tolylpyrazolo[5,1-a]isoquinoline

5-(4-bromophenyl)-2-phenylpyrazolo[5,1-a]isoquinoline

2-phenyl-5-(thiophen-3-yl)pyrazolo[5,1-a]isoquinoline