(E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile

Base Information

• Chemical Name: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile
• CAS No.: 114567-01-0
• Molecular Formula: C₁₁H₁₁ClN₂
• Molecular Weight: 206.675
• Mol file: 114567-01-0.mol

Synonyms:(E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile

Chemical Property of (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile

There total 1 articles about (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + p-chlorobenzyl cyanide (140-53-4) → (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile (114567-01-0)

Guidance literature:

at 80 ℃; for 2h;

Reference yield: 90.0%

(E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile (114567-01-0) → 2-(4-Chlorophenyl)-2-propenenitrile (27179-74-4)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; at 20 ℃; for 1.5h;

Reference yield:

(E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile (114567-01-0) → (+)-Saclofen (125464-42-8,162894-54-4,162894-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaBH₃CN, AcOH, 2.) NaIO₄ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) H₂O, r.t., 16 h

2: 71 percent / NaHSO₃ / methanol; H₂O / 8 h / Heating

3: 59 percent / H₂, 6 percent aq. NH₃ / Raney Ni / 2 h / 2550.2 Torr / Ambient temperature

With ammonium hydroxide; sodium periodate; hydrogen; sodium cyanoborohydride; sodium hydrogensulfite; acetic acid; nickel; In methanol; water;

DOI:10.1055/s-1991-26437

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

p-chlorobenzyl cyanide

Downstream raw materials:

2-(4-Chlorophenyl)-2-propenenitrile

(+)-Saclofen

Sodium 2-(4-Chlorophenyl)-2-cyanoethylsulfonate