27179-74-4

Basic information

• Product Name: 2-(4-Chlorophenyl)-2-propenenitrile
• Synonyms: 2-(4-Chlorophenyl)-2-propenenitrile
• CAS NO: 27179-74-4
• Molecular Weight: 163.606
• Mol File: 27179-74-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-Chlorophenyl)-2-propenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-2-propenenitrile(27179-74-4)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-2-propenenitrile(27179-74-4)

Safety Data

• Hazardous Substances Data: 27179-74-4(Hazardous Substances Data)

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 1073-67-2 4-vinylbenzyl chloride 
• 7677-24-9 trimethylsilyl cyanide 
• 50-00-0 formaldehyd 
• 557-21-1 zinc(II) cyanide 
• 873-73-4 4-n-chlorophenylacetylene 
• 38747-00-1 ethyl 3-(4-chlorophenyl)-3-cyano-2-oxopropanoate 
• 114567-01-0 (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile 

Downstream Products

• 92520-15-5 (R)-N-[1-(4-chlorophenyl)ethyl]acetamide 
• 133809-10-6 (R)-(-)-2-(4'-chlorophenyl)propionamide 
• 2184-88-5 2-(4-chlorophenyl)propionitrile 
• 125464-42-8 (+)-Saclofen 
• 134589-61-0 Sodium 2-(4-Chlorophenyl)-2-cyanoethylsulfonate 

Relevant articles and documents

Method for preparing alkenyl cyanide compounds

The invention discloses a method for preparing alkenyl cyanide compounds represented by formula II. Alkynes represented by formula I and a cyanation reagent are subjected to a reduction reaction represented by a formula shown in the description in an organic solvent under the protection of a gas at 20-100 DEG C under the action of a nickel catalyst, a reducing agent and H2O to prepare the alkenyl cyanide compounds represented by formula II. The preparation method of the invention, which adopts the cheap nickel as the catalytic system, has the advantages of simplicity in operation, mild reaction conditions, good compatibility of functional groups, wide application range of the substrate, high reaction efficiency and high yield, so the method has high application and promotion values.

Nickel-Catalyzed Highly Regioselective Hydrocyanation of Terminal Alkynes with Zn(CN)2 Using Water as the Hydrogen Source

The first efficient and general nickel-catalyzed hydrocyanation of terminal alkynes with Zn(CN)2 in the presence of water has been developed. The reaction provides a regioselective protocol for the synthesis of functionalized vinyl nitriles with a range of structural diversity under mild reaction conditions while obviating use of the volatile and hazardous reagent of HCN. Deuterium-labeling experiments confirmed the role of water as the hydrogen source in this hydrocyanation reaction.

Esters of 2-phenylalkanenitriles and antifungal compositions containing them

Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.