C₂₆H₂₄N₂O₂S

Base Information

• Chemical Name: C₂₆H₂₄N₂O₂S
• CAS No.: 1285665-54-4
• Molecular Formula: C₂₆H₂₄N₂O₂S
• Molecular Weight: 428.555
• Mol file: 1285665-54-4.mol

Synonyms:C₂₆H₂₄N₂O₂S

Chemical Property of C₂₆H₂₄N₂O₂S

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₄N₂O₂S

There total 3 articles about C₂₆H₂₄N₂O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-methyl-2-phenylpyridine (46181-30-0) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → C26H24N2O2S (1285665-54-4)

Guidance literature:

With [Cp*Rh(CH₃CN)3][SbF₆]2; In tert-butyl alcohol; at 90 ℃; for 10h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201007464

Reference yield: 66.0%

6-methyl-2-phenylpyridine (46181-30-0) + benzaldehyde dimethyl acetal (1125-88-8) + toluene-4-sulfonamide (70-55-3) → C26H24N2O2S (1285665-54-4)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In tetrahydrofuran; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201903414

Reference yield:

2-bromo-6-methylpyridine (5315-25-3) + bromobenzene (108-86-1,52753-63-6) → C26H24N2O2S (1285665-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc; trifluoroacetic acid; ethylene dibromide; cobalt(II) bromide / acetonitrile / 1 h / 20 °C / Inert atmosphere; Sealed tube

1.2: 1 h / 50 °C / Inert atmosphere; Sealed tube

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / tetrahydrofuran / 16 h / 120 °C / Inert atmosphere; Sealed tube

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; ethylene dibromide; trifluoroacetic acid; cobalt(II) bromide; zinc; In tetrahydrofuran; acetonitrile; 2.1: |Mannich Aminomethylation;

DOI:10.1002/chem.201903414

upstream raw materials:

6-methyl-2-phenylpyridine

N-(benzylidene)-p-methylbenzenesulfonamide

benzaldehyde dimethyl acetal

toluene-4-sulfonamide