[⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

Base Information

• Chemical Name: [⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
• CAS No.: 1415914-06-5
• Molecular Formula: C₂₀H₁₈F₃N₅O₃
• Molecular Weight: 435.382

Synonyms:[⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

Chemical Property of [⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

There total 9 articles about [⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(but-2-yn-1-yloxy)pyrazine-2-carboxylic acid (1221447-98-8) + [(3)H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine (1415914-08-7) → [(3)H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide (1415914-06-5)

Guidance literature:

5-(but-2-yn-1-yloxy)pyrazine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 ℃; for 2h;

[⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine; In methanol; at 0 - 20 ℃; for 18h;

Reference yield:

1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) → [(3)H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide (1415914-06-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: titanium(IV) oxide / tetrahydrofuran / Reflux

2.1: zinc / diethyl ether / 5 h / Inert atmosphere; Reflux

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 23 °C

5.1: ethanol / 23 °C / Inert atmosphere; Sealed tube

6.1: hydrogen / palladium-on-charcoal / ethanol / 1 h / 23 °C

7.1: dihydrogen peroxide; ammonium iodide / water; acetic acid / 20 °C

8.1: triethylamine; tritium / palladium-on-charcoal / ethyl acetate / 4 h / 532.55 Torr

9.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 2 h / 0 °C

9.2: 18 h / 0 - 20 °C

With hydrogenchloride; ammonium iodide; lithium borohydride; tritium; hydrogen; dihydrogen peroxide; titanium(IV) oxide; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; zinc; palladium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; acetic acid; ethyl acetate; 2.1: Reformatsky Reaction;

Reference yield:

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide (1075230-62-4) → [(3)H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide (1415914-06-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: zinc / diethyl ether / 5 h / Inert atmosphere; Reflux

2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 23 °C

4.1: ethanol / 23 °C / Inert atmosphere; Sealed tube

5.1: hydrogen / palladium-on-charcoal / ethanol / 1 h / 23 °C

6.1: dihydrogen peroxide; ammonium iodide / water; acetic acid / 20 °C

7.1: triethylamine; tritium / palladium-on-charcoal / ethyl acetate / 4 h / 532.55 Torr

8.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 2 h / 0 °C

8.2: 18 h / 0 - 20 °C

With hydrogenchloride; ammonium iodide; lithium borohydride; tritium; hydrogen; dihydrogen peroxide; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; zinc; palladium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; acetic acid; ethyl acetate; 1.1: Reformatsky Reaction;

upstream raw materials:

1-(2-fluoro-5-nitrophenyl)ethanone

(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

(R)-2-methylpropane-2-sulfinic acid [(R)-2,2-difluoro-1-(2-fluoro-5-nitrophenyl)-3-hydroxy-1-methylpropyl]amide

(R)-3-amino-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)butan-1-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1415914-06-5 [⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send