{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

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Chemical Name:{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid
CAS No.:80682-14-0
Molecular Formula:C₃₀H₃₆N₆O₁₂S₂
Molecular Weight:736.781
Hs Code.:

{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

Synonyms:{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

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Chemical Property of {(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

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Technology Process of {(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

There total 5 articles about {(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 80682-15-1
{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(methoxycarbonylmethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid methyl ester

: 80682-14-0
{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 25 ℃; for 3h;
DOI:10.1021/ja00414a075

Reference yield:

: 10389-65-8
di-t-butoxycarbonyl-L-cystine

: 80682-14-0
{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

2: CF₃CO₂H / CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

4: 85 percent / 0.1 M NaOH / methanol; H₂O / 3 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; trifluoroacetic acid; isobutyl chloroformate; In methanol; dichloromethane; water;
DOI:10.1021/ja00414a075

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 80682-14-0
{(R)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-2-(carboxymethyl-carbamoyl)-ethyldisulfanyl]-propionylamino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

2: 85 percent / 0.1 M NaOH / methanol; H₂O / 3 h / 25 °C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In methanol; water;
DOI:10.1021/ja00414a075