Technology Process of Cyclopentanecarboxylic acid, 2-amino-3-methyl-, (1R,2S,3R)-rel- (9CI)
There total 13 articles about Cyclopentanecarboxylic acid, 2-amino-3-methyl-, (1R,2S,3R)-rel- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (αS)-2-[n-benzyl-N-(α-methylbenzyl)-amino]-3-methylcyclopentanecarboxylate;
With
hydrogen;
palladium dihydroxide;
In
methanol;
under 3800 Torr;
With
trifluoroacetic acid;
In
dichloromethane;
DOI:10.1039/b209728c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaH; t-BuOH / toluene / Heating
2.1: NaH; n-BuLi / -78 °C
2.2: 91 percent / -78 - 0 °C
3.1: NaBH4 / ethanol / 0 °C
4.1: pyridine / 0 - 20 °C
5.1: DBU / CH2Cl2 / 0 °C
6.1: tetrahydrofuran / 3 h / -78 °C
6.2: 2,6-di-tert-butylphenol / tetrahydrofuran / -78 - 20 °C
7.1: H2 / Pd(OH)2/C / methanol / 3800 Torr
7.2: 69 percent / TFA / CH2Cl2
With
pyridine; sodium tetrahydroborate; n-butyllithium; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
1.1: Dieckmann cyclisation;
DOI:10.1039/b209728c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaH; n-BuLi / -78 °C
1.2: 91 percent / -78 - 0 °C
2.1: NaBH4 / ethanol / 0 °C
3.1: pyridine / 0 - 20 °C
4.1: DBU / CH2Cl2 / 0 °C
5.1: tetrahydrofuran / 3 h / -78 °C
5.2: 2,6-di-tert-butylphenol / tetrahydrofuran / -78 - 20 °C
6.1: H2 / Pd(OH)2/C / methanol / 3800 Torr
6.2: 69 percent / TFA / CH2Cl2
With
pyridine; sodium tetrahydroborate; n-butyllithium; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1039/b209728c