2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester
• CAS No.: 110087-69-9
• Molecular Formula: C₂₆H₄₂O₆
• Molecular Weight: 450.616

Synonyms:2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

Chemical Property of 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

There total 18 articles about 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-[(4S,5R,6S)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-hexyl ester (110087-68-8) → 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester (110087-69-9)

Guidance literature:

With n-Bu₄F; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)85204-1

Reference yield:

methyl 4,6-O-benzylidene-2-deoxy-2-(2-propenyl)-α-D-allohexopyranoside (126108-10-9) → 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester (110087-69-9)

Guidance literature:

Multi-step reaction with 17 steps

1: CSA, CH₃OH

3: 1.) phosgene iminium chloride

4: toluene / 100 °C

5: 85 percent / H₂SO₄ / tetrahydrofuran; H₂O / 25 °C

6: 62 percent / PdCl₂/CuCl₂/O₂ / dimethylformamide; H₂O / 25 °C

7: 87 percent / PDC / acetic anhydride; CH₂Cl₂

8: 91 percent / LiAlH₄ / diethyl ether

9: 88 percent / pyridine

10: 60 percent / BF₃*Et₂O

11: 92 percent / imidazole

12: HgCl₂, CaCO₃ / acetonitrile; H₂O

13: 58 percent / tetrahydrofuran

14: 95 percent / PPTS

15: 1.) BH₃*THF, 2.) 3N NaOH, 30percent H₂O₂

16: 72 percent / NaH, n-Bu₄NI / dimethylformamide

17: 90 percent / n-Bu₄F / tetrahydrofuran

With pyridine; 1H-imidazole; methanol; sodium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; borane-THF; sulfuric acid; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; dihydrogen peroxide; oxygen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; dichloromethylenedimethyliminium chloride; calcium carbonate; mercury dichloride; copper dichloride; palladium dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic anhydride; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/S0040-4039(00)85204-1

Reference yield:

(1S,2R,3R,4S,5R)-4-(3-Hydroxy-propyl)-2-methyl-6,8-dioxa-bicyclo[3.2.1]octan-3-ol (110087-61-1) → 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester (110087-69-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 88 percent / pyridine

2: 60 percent / BF₃*Et₂O

3: 92 percent / imidazole

4: HgCl₂, CaCO₃ / acetonitrile; H₂O

5: 58 percent / tetrahydrofuran

6: 95 percent / PPTS

7: 1.) BH₃*THF, 2.) 3N NaOH, 30percent H₂O₂

8: 72 percent / NaH, n-Bu₄NI / dimethylformamide

9: 90 percent / n-Bu₄F / tetrahydrofuran

With pyridine; 1H-imidazole; sodium hydroxide; borane-THF; boron trifluoride diethyl etherate; dihydrogen peroxide; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; calcium carbonate; mercury dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)85204-1

upstream raw materials:

2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-[(4S,5R,6S)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-hexyl ester

methyl 4,6-O-benzylidene-2-deoxy-2-(2-propenyl)-α-D-allohexopyranoside

(1S,2R,3R,4S,5R)-4-(3-Hydroxy-propyl)-2-methyl-6,8-dioxa-bicyclo[3.2.1]octan-3-ol

(1R,2S,7R,8R,9S)-8-Methyl-6,11,12-trioxa-tricyclo[7.2.1.0^2,7]dodecan-5-ol

Downstream raw materials:

2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-formyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-[(4S,5S,6R)-6-(2-hydroxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-hexyl ester

2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5S,6R)-2,2,5-trimethyl-6-vinyl-[1,3]dioxan-4-yl)-hexyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 110087-69-9 2,2-Dimethyl-propionic acid (S)-6-benzyloxy-4-((4S,5R,6S)-6-hydroxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send