(E)-2-cyclohexyl-4-styrylquinazoline

Base Information

• Chemical Name: (E)-2-cyclohexyl-4-styrylquinazoline
• CAS No.: 1451360-15-8
• Molecular Formula: C₂₂H₂₂N₂
• Molecular Weight: 314.43
• Mol file: 1451360-15-8.mol

Synonyms:(E)-2-cyclohexyl-4-styrylquinazoline

Chemical Property of (E)-2-cyclohexyl-4-styrylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-cyclohexyl-4-styrylquinazoline

There total 2 articles about (E)-2-cyclohexyl-4-styrylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-cyclohexylquinazoline (1438279-38-9) + phenylacetylene (536-74-3) → (E)-2-cyclohexyl-4-styrylquinazoline (1451360-15-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 40 ℃; for 0.5h;

DOI:10.1039/c3ob41083h

Reference yield:

o-aminobenzaldehyde (529-23-7) → (E)-2-cyclohexyl-4-styrylquinazoline (1451360-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 °C

2: ammonium hydroxide / isopropyl alcohol / 10 h / 90 °C / Sealed tube

3: potassium tert-butylate / tetrahydrofuran / 0.5 h / 40 °C

With ammonium hydroxide; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1039/c3ob41083h

upstream raw materials:

2-cyclohexylquinazoline

phenylacetylene

o-aminobenzaldehyde