2-cyclohexylquinazoline

Base Information

• Chemical Name: 2-cyclohexylquinazoline
• CAS No.: 1438279-38-9
• Molecular Formula: C₁₄H₁₆N₂
• Molecular Weight: 212.294
• Mol file: 1438279-38-9.mol

Synonyms:2-cyclohexylquinazoline

Chemical Property of 2-cyclohexylquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclohexylquinazoline

There total 7 articles about 2-cyclohexylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-amino-1-benzylamine (4403-69-4) + cyclohexanecarbaldehyde (2043-61-0) → 2-cyclohexylquinazoline (1438279-38-9)

Guidance literature:

2-amino-1-benzylamine; cyclohexanecarbaldehyde; In chloroform; at 35 ℃; for 4h;

With 3,3,3',3'-tetramethyl-2,3,2',3'-tetrahydro-[1,1']spirobiindene-5,6,5',6'-tetraol; oxygen; potassium carbonate; In chloroform; water; at 35 ℃; for 16h; under 760.051 Torr;

DOI:10.1002/adsc.201200880

Reference yield: 95.0%

2-cyclohexyl-1,2,3,4-tetrahydroquinazoline (1514933-79-9) → 2-cyclohexylquinazoline (1438279-38-9)

Guidance literature:

With diethylazodicarboxylate; In acetonitrile; at 20 ℃; for 0.833333h;

DOI:10.1039/c7ra09165f

Reference yield: 68.0%

2-Aminobenzyl alcohol (5344-90-1) + cyclohexylcarboxamide (1122-56-1) → 2-cyclohexylquinazoline (1438279-38-9)

Guidance literature:

With bromopentacarbonylmanganese(I); N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium tert-butylate; In toluene; at 130 ℃; for 36h; Sealed tube; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.0c00561

upstream raw materials:

2-amino-1-benzylamine

cyclohexanecarbaldehyde

cyclohexanylcarbonyl chloride

N-(2-formylphenyl)cyclohexanecarboxamide

Downstream raw materials:

(E)-2-cyclohexyl-4-styrylquinazoline