(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

Base Information

Chemical Name:(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate
CAS No.:499140-16-8
Molecular Formula:C₂₁H₂₇NO₄S
Molecular Weight:389.516
Hs Code.:

Synonyms:(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

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Chemical Property of (1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

Chemical Property:

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Technology Process of (1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

There total 4 articles about (1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 677-22-5
tert-butylmagnesium chloride

: 499140-12-4
benzyl (2R,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxilate

: 499140-16-8
(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

Guidance literature:: In dichloromethane; at -40 ℃;
DOI:10.1021/ol027232i

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 499140-16-8
(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 0.08 h / 0 °C

2: thionyl chloride; 2,6-lutidine / CH₂Cl₂ / 0.25 h / -40 °C

3: 82 percent / CH₂Cl₂ / -40 °C

With 2,6-dimethylpyridine; dmap; thionyl chloride; In dichloromethane;
DOI:10.1021/ol027232i

Reference yield:

: 104863-92-5
(1R,2S)-1-phenyl-2-benzyloxycarbonylamino-1-propanol

: 499140-16-8
(1R,2S)-2-{[(benzyloxy)carbonyl]amino}-1-phenylpropyl (S)-2-methylpropane-2-sulfinate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; 2,6-lutidine / CH₂Cl₂ / 0.25 h / -40 °C

2: 82 percent / CH₂Cl₂ / -40 °C

With 2,6-dimethylpyridine; thionyl chloride; In dichloromethane;
DOI:10.1021/ol027232i