2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

Base Information

Chemical Name:2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine
CAS No.:1049707-80-3
Molecular Formula:C₁₈H₁₆ClF₃N₂O₃Si
Molecular Weight:428.87
Hs Code.:

Synonyms:2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

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Chemical Property of 2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

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Technology Process of 2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

There total 6 articles about 2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1049707-75-6
3-bromo-2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitropyridine

: 1066-54-2
trimethylsilylacetylene

: 1049707-80-3
2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

Guidance literature:: 3-bromo-2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitropyridine; With diisopropylamine; at 20 ℃; for 0.333333h;

trimethylsilylacetylene; With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; at 70 ℃; for 5h;

Reference yield:

: 3279-76-3,91914-07-7
6-hydroxy-2-methylpyridine

: 1049707-80-3
2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / acetonitrile / 2.17 h / 0 - 29 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -80 - -74 °C / Cooling with ether-dry ice

2.2: -78 - 20 °C

3.1: nitric acid / water / 3.5 h / 0 - 20 °C

3.2: pH 4

4.1: trichlorophosphate / 7 h / Heating / reflux

5.1: sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane / 1,4-dioxane / 0.5 h / 20 °C

5.2: 22 h / 20 °C

6.1: diisopropylamine / 0.33 h / 20 °C

6.2: 5 h / 70 °C

With N-Bromosuccinimide; n-butyllithium; nitric acid; sodium hydride; diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; water; acetonitrile;

Reference yield:

: 374633-33-7
3-bromo-2-hydroxy-6-methylpyridine

: 1049707-80-3
2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid / water / 3.5 h / 0 - 20 °C

1.2: pH 4

2.1: trichlorophosphate / 7 h / Heating / reflux

3.1: sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane / 1,4-dioxane / 0.5 h / 20 °C

3.2: 22 h / 20 °C

4.1: diisopropylamine / 0.33 h / 20 °C

4.2: 5 h / 70 °C

With nitric acid; sodium hydride; diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In 1,4-dioxane; water;