cyclohexyl 2-pyridinesulfonate

Base Information

• Chemical Name: cyclohexyl 2-pyridinesulfonate
• CAS No.: 117800-88-1
• Molecular Formula: C₁₁H₁₅NO₃S
• Molecular Weight: 241.311
• Mol file: 117800-88-1.mol

Synonyms:cyclohexyl 2-pyridinesulfonate

Chemical Property of cyclohexyl 2-pyridinesulfonate

Chemical Property:

Purity/Quality:

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Technology Process of cyclohexyl 2-pyridinesulfonate

There total 2 articles about cyclohexyl 2-pyridinesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pyridine-2-sulfonyl chloride (66715-65-9) + cyclohexanol (108-93-0) → cyclohexyl 2-pyridinesulfonate (117800-88-1)

Guidance literature:

With triethylamine; at 2 ℃; for 3h;

DOI:10.1021/jo00263a024

Reference yield:

2-Sulfanylpyridine (2637-34-5,73018-10-7) → cyclohexyl 2-pyridinesulfonate (117800-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Cl₂, aq. HCl / 0.5 h / 5 °C

2: 85 percent / triethylamine / 3 h / 2 °C

With hydrogenchloride; chlorine; triethylamine;

DOI:10.1021/jo00263a024

Reference yield: 81.0%

cyclohexyl 2-pyridinesulfonate (117800-88-1) → 2-(cyclohexyloxy)pyridine (52200-47-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 1h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02858

upstream raw materials:

pyridine-2-sulfonyl chloride

cyclohexanol

2-Sulfanylpyridine

Downstream raw materials:

2-(cyclohexyloxy)pyridine