1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

Base Information

Chemical Name:1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea
CAS No.:1442473-19-9
Molecular Formula:C₂₃H₁₉BrFN₅O₂
Molecular Weight:496.339
Hs Code.:

Synonyms:1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

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Chemical Property of 1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

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Technology Process of 1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

There total 12 articles about 1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1442473-17-7
3-(5-amino-2-bromo-4-fluoro-phenyl)-1-methyl-7-methylamino-1H-[1,6]naphthyridin-2-one

: 103-71-9
phenyl isocyanate

: 1442473-19-9
1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1442473-19-9
1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 6 steps

1: water; acetonitrile / 8 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

3: manganese(IV) oxide / dichloromethane / 6 h / 30 °C

4: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

5: ethanol / 24 h / 120 °C

6: triethylamine / dichloromethane / 12 h / 20 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1442473-19-9
1-(4-bromo-2-fluoro-5-(1-methyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)phenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

2: ethanol / 24 h / 120 °C

3: triethylamine / dichloromethane / 12 h / 20 °C

With aluminum oxide; potassium fluoride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide;