N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

Base Information

Chemical Name:N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide
CAS No.:774226-93-6
Molecular Formula:C₃₆H₅₈N₄O₆
Molecular Weight:642.88
Hs Code.:

Synonyms:N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

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Chemical Property of N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

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Technology Process of N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

There total 7 articles about N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 774226-91-4
N^α-{[(2R-N-benzyloxy-N-formylamino)methyl]-6-heptenoyl}-N-(10-undecen-1-yl)-N^ε-tert-butoxycarbonyl-L-lysinamide

: 774226-93-6
N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 40 ℃; for 20h;
DOI:10.1021/jm049592c

Reference yield:

: 62595-52-2
undec-10-en-1-amine

: 774226-93-6
N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2 h

2: 87 percent / piperidine / CH₂Cl₂ / 0.67 h

3: 85 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂

4: 84 percent / Grubb's catalyst (Pcy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 h / 40 °C

With piperidine; Grubbs catalyst first generation; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1021/jm049592c

Reference yield:

: 112-43-6
10-Undecen-1-ol

: 774226-93-6
N-{3-[4-(tert-butoxycarbonylamino)butyl]-2,5-dioxo-1,4-diazacycloicos-10-en-6-yl}methyl-N-benzyloxyformamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂ / 2 h

2: aq. sodium azide / dimethylformamide / 50 °C

3: LiAlH₄ / diethyl ether

4: 82 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2 h

5: 87 percent / piperidine / CH₂Cl₂ / 0.67 h

6: 85 percent / triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂

7: 84 percent / Grubb's catalyst (Pcy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / 20 h / 40 °C

With piperidine; lithium aluminium tetrahydride; Grubbs catalyst first generation; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049592c