(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

Base Information

Chemical Name:(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate
CAS No.:534572-16-2
Molecular Formula:C₄₉H₆₁NO₁₃Si
Molecular Weight:900.108
Hs Code.:

Synonyms:(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

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Chemical Property of (7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

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Technology Process of (7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

There total 1 articles about (7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 115437-21-3
7-(triethylsilyl)baccatin III

: 534572-15-1
(+/-)-2-phenylspiro(cyclopropane-1',4-oxazoline)-5-carboxylic acid

: 534572-18-4
(7-TES-baccatin III)-13-yl (5R)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

: 534572-16-2
(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

Guidance literature:: With dicyclohexyl-carbodiimide; In toluene; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(03)00176-X DOI:10.1002/ejoc.200500243

Reference yield: 97.0%

: 534572-16-2
(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

: 534572-31-1
(baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200500243

Reference yield:

: 534572-16-2
(7-TES-baccatin III)-13-yl (5S)-2-phenylspiro[cyclopropane-1',4-oxazoline]-5-carboxylate

: 534572-25-3
3'-dephenyl-3',3'-ethylene-2',7-epi-taxol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / pyridine; HF / tetrahydrofuran / 20 °C

2.1: HCl / dioxane; H₂O / 1 h / 50 °C

2.2: 32 percent / NaHCO₃ / dioxane; H₂O / 20 °C

With pyridine; hydrogenchloride; hydrogen fluoride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1002/ejoc.200500243