di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide

Base Information

• Chemical Name: di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide
• CAS No.: 438497-31-5
• Molecular Formula: C₂₀H₂₆O₂S₂Se₂
• Molecular Weight: 520.477
• Mol file: 438497-31-5.mol

Synonyms:di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide

Chemical Property of di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide

There total 4 articles about di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-methoxy-3-[(1S)-1-(methylthio)ethyl]benzene (438497-32-6) → di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide (438497-31-5)

Guidance literature:

1-methoxy-3-[(1S)-1-(methylthio)ethyl]benzene; With tert.-butyl lithium; In pentane; at -78 - 25 ℃; for 0.75h;

With selenium; In tetrahydrofuran; pentane; at 20 ℃; for 12h; Further stages.;

DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2

Reference yield:

(R)-(+)-1-(3-methoxyphenyl)-1-ethanol (23308-82-9,89691-63-4,120523-12-8,129940-69-8) → di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide (438497-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KOH / diethyl ether / 24 h / -20 °C

2.1: diethyl ether / 12 h / 20 °C

3.1: t-BuLi / pentane / 0.75 h / -78 - 25 °C

3.2: 70 percent / Se / pentane; tetrahydrofuran / 12 h / 20 °C

With potassium hydroxide; tert.-butyl lithium; In diethyl ether; pentane;

DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2

Reference yield:

1-(3-Methoxyphenyl)ethanone (586-37-8) → di-[2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl]diselenide (438497-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: (+)-β-chlorodiisopinocampheylborane / tetrahydrofuran / -20 °C

2.1: KOH / diethyl ether / 24 h / -20 °C

3.1: diethyl ether / 12 h / 20 °C

4.1: t-BuLi / pentane / 0.75 h / -78 - 25 °C

4.2: 70 percent / Se / pentane; tetrahydrofuran / 12 h / 20 °C

With potassium hydroxide; tert.-butyl lithium; B-chlorodiisopinocampheylborane; In tetrahydrofuran; diethyl ether; pentane;

DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2

upstream raw materials:

1-methoxy-3-[(1S)-1-(methylthio)ethyl]benzene

(R)-(+)-1-(3-methoxyphenyl)-1-ethanol

1-(3-Methoxyphenyl)ethanone

Downstream raw materials:

C₁₁H₁₃F₃O₄S₂Se

C₁₀H₁₃BrOSSe

2-[({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)methyl]-5-methyl-3,4-dihydro-2H-pyrrole 1-oxide