C₂₂H₃₀FNO₄

Base Information

• Chemical Name: C₂₂H₃₀FNO₄
• CAS No.: 1622935-29-8
• Molecular Formula: C₂₂H₃₀FNO₄
• Molecular Weight: 391.483
• Mol file: 1622935-29-8.mol

Synonyms:C₂₂H₃₀FNO₄

Chemical Property of C₂₂H₃₀FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₀FNO₄

There total 7 articles about C₂₂H₃₀FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 2-(2-hydroxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoate (1613033-24-1) + 2-fluoroethyl tosylate (383-50-6) → C22H30FNO4 (1622935-29-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 17.5h;

DOI:10.1016/j.bmc.2014.04.059

Reference yield:

2-(phenylmethoxy)benzaldehyde (5896-17-3) → C22H30FNO4 (1622935-29-8)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium hydroxide / dimethyl sulfoxide / 15 h / 80 °C

2: sodium hydroxide; water / dimethyl sulfoxide / 5 h / 120 °C

3: acetic anhydride / dichloromethane / 1.5 h / 60 °C

4: dichloromethane / 5 h / 0 - 20 °C

5: thionyl chloride / 15.5 h / 0 - 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

7: caesium carbonate / N,N-dimethyl-formamide / 17.5 h / 60 °C

With thionyl chloride; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; caesium carbonate; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.059

Reference yield:

2-(2-benzyloxybenzylidene)succinic acid (1613033-20-7) → C22H30FNO4 (1622935-29-8)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic anhydride / dichloromethane / 1.5 h / 60 °C

2: dichloromethane / 5 h / 0 - 20 °C

3: thionyl chloride / 15.5 h / 0 - 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

5: caesium carbonate / N,N-dimethyl-formamide / 17.5 h / 60 °C

With thionyl chloride; palladium 10% on activated carbon; hydrogen; acetic anhydride; caesium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.04.059

upstream raw materials:

2-(phenylmethoxy)benzaldehyde

2-(2-benzyloxybenzylidene)succinic acid

methyl 2-(2-benzyloxybenzylidene)-4-oxo-4-(cis-3a,4,7,7a-tetrahydroisoindolin-2-yl)butanoate

methyl 2-(2-hydroxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoate

Downstream raw materials:

2-(2-fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid

2-(2-fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid

2-(2-fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid

C₂₁H₃₀FNO₃