3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole

Base Information

• Chemical Name: 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole
• CAS No.: 329977-73-3
• Molecular Formula: C₁₅H₁₈ClFN₂O
• Molecular Weight: 296.772
• Mol file: 329977-73-3.mol

Synonyms:3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole

Chemical Property of 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-(1-(3-Chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole

There total 13 articles about 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-fluoro-3-[1-(3-hydroxypropyl)-4-piperidinyl]-1,2-benzisoxazole (150332-87-9) → 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole (329977-73-3)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.oprd.6b00220

Reference yield: 85.0%

3-chloro-1-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propan-1-one → 3-(1-allyl-4-piperidyl)-6-fluoro-1,2-benzisoxazole + 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole (329977-73-3) + C15H19FN2O (1403488-79-8)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 5 ℃; for 2h; Reagent/catalyst; Large scale;

DOI:10.1021/acs.oprd.6b00220

Reference yield: 80.0%

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (84163-13-3) + 1.3-chlorobromopropane (109-70-6) → 3-(1-(3-chloropropyl)piperidin-4-yl)-6-fluorobenzo[d]isoxazole (329977-73-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17.5h;

upstream raw materials:

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

1.3-chlorobromopropane

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

3-chloropropyl p-toluenesulfonate