5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

Base Information

Chemical Name:5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid
CAS No.:868836-06-0
Molecular Formula:C₂₃H₃₇N₃O₅
Molecular Weight:435.564
Hs Code.:

Synonyms:5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

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Chemical Property of 5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

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Technology Process of 5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

There total 6 articles about 5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

: 868836-01-5
5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanoic acid

: 868836-06-0
5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

Guidance literature:: 5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With hydroxylamine; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm0505009

Reference yield: 80.9%

: 868836-06-0
5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

Guidance literature:

Reference yield:

: 868835-93-2
1-N-[4-(methyl)benzyl]-1-N-[(tert-butyloxy)carbonyl]-4-aminobutylamine

: 868836-06-0
5-{4-[(tert-butyloxy)carbonyl]-[4-(methyl)benzyl]amino}butylcarbamoylpentanohydroxamic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70.7 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2.1: 70.9 percent / aq. LiOH / tetrahydrofuran / 0 - 20 °C

3.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3.2: 80.9 percent / hydroxylamine / methanol; tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0505009