N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine

Base Information

• Chemical Name: N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine
• CAS No.: 1380672-68-3
• Molecular Formula: C₁₀H₁₀ClN₅O
• Molecular Weight: 251.675
• Mol file: 1380672-68-3.mol

Synonyms:N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine

Chemical Property of N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine

There total 1 articles about N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamide (1380672-67-2) + (Z)-2-chloro-N-(chloro(3-methyl-1,2,4-oxadiazol-5-yl)methylene)benzenamine (1380672-87-6) → N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine (1380672-68-3)

Guidance literature:

N-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamide; With phosphorus pentachloride; In benzene; for 16h; Reflux;

(Z)-2-chloro-N-(chloro(3-methyl-1,2,4-oxadiazol-5-yl)methylene)benzenamine; With hydrazine hydrate; In tetrahydrofuran; at 20 ℃; for 3h; Cooling with ice;

Reference yield: 28.0%

N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine (1380672-68-3) + (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid (1380672-63-8) → 4-(5-((E)-2-(4-(2-chlorophenyl)-5-(3-methyl-1,2,4-oxadiazol-5-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine (1380672-03-6)

Guidance literature:

(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid; With trichlorophosphate; In acetonitrile; at 20 ℃; for 16h; Reflux;

N-amino-N'-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamidine; With potassium carbonate; In acetonitrile; at 20 ℃; for 3h; Reflux;

upstream raw materials:

N-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamide

(Z)-2-chloro-N-(chloro(3-methyl-1,2,4-oxadiazol-5-yl)methylene)benzenamine

Downstream raw materials:

4-(5-((E)-2-(4-(2-chlorophenyl)-5-(3-methyl-1,2,4-oxadiazol-5-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)-2-methoxypyridine