S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate

Base Information

• Chemical Name: S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate
• CAS No.: 1170733-38-6
• Molecular Formula: C₂₃H₂₄FN₃O₁₀S
• Molecular Weight: 553.522
• Mol file: 1170733-38-6.mol

Synonyms:S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate

Chemical Property of S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate

There total 2 articles about S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

phosgene (75-44-5) + paroxetine (61869-08-7) + GT 150 (349472-66-8) → S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate (1170733-38-6)

Guidance literature:

phosgene; paroxetine; With triethylamine; In dichloromethane; toluene; at 0 - 20 ℃; for 12h;

GT 150; In dichloromethane; at 0 - 20 ℃;

Reference yield: 65.0%

phosgene (75-44-5) + (R)-3-mercaptopropane-1,2-diyl dinitrate (1316288-60-4) + paroxetine (61869-08-7) → S-(2,3-di(nitrooxy)propyl) (3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbothioate (1170733-38-6)

Guidance literature:

phosgene; paroxetine; With triethylamine; In dichloromethane; toluene; at 0 - 25 ℃; for 12h; Inert atmosphere;

(R)-3-mercaptopropane-1,2-diyl dinitrate; With triethylamine; In dichloromethane; toluene; at 0 - 25 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ml2000033

upstream raw materials:

phosgene

paroxetine

GT 150

(R)-3-mercaptopropane-1,2-diyl dinitrate