ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate

Base Information

• Chemical Name: ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate
• CAS No.: 1207984-43-7
• Molecular Formula: C₁₇H₂₄F₃NO₂
• Molecular Weight: 331.378
• Mol file: 1207984-43-7.mol

Synonyms:ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate

Chemical Property of ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate

There total 1 articles about ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 7-bromoheptanoate (29823-18-5) + 3-(trifluoromethyl)-4-methylaniline (65934-74-9) → ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate (1207984-43-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 70 ℃; for 18h; Inert atmosphere;

Reference yield:

ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate (1207984-43-7) → ethyl 7-{[4-methyl-2-nitro-5-(trifluoromethyl)phenyl]amino}heptanoate (1207984-44-8)

Guidance literature:

ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate; With nitric acid; acetic anhydride; acetic acid; at 10 ℃; for 72h;

With sodium hydrogencarbonate; In n-heptane; water;

Reference yield:

ethyl 7-{[4-methyl-3-(trifluoromethyl)phenyl]amino}heptanoate (1207984-43-7) → ethyl 7-{[2amino-4-methyl-5-(trifluoromethyl)phenyl]amino}heptanoate (1207984-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic anhydride; acetic acid / 72 h / 10 °C

2: hydrogen / Raney nickel / ethanol; water / Inert atmosphere

With hydrogen; nitric acid; acetic anhydride; acetic acid; Raney nickel; In ethanol; water;

upstream raw materials:

ethyl 7-bromoheptanoate

3-(trifluoromethyl)-4-methylaniline

Downstream raw materials:

ethyl 7-{[4-methyl-2-nitro-5-(trifluoromethyl)phenyl]amino}heptanoate

ethyl 7-{[2amino-4-methyl-5-(trifluoromethyl)phenyl]amino}heptanoate