1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

Base Information

Chemical Name:1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea
CAS No.:1251899-84-9
Molecular Formula:C₂₂H₂₅F₃N₆O₃
Molecular Weight:478.474
Hs Code.:

Synonyms:1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

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Chemical Property of 1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

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Technology Process of 1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

There total 8 articles about 1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 1251899-94-1
C₁₉H₁₇ClF₃N₅O₂

: 1251899-84-9
1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: In ISOPROPYLAMIDE; at 20 ℃; for 18h;

Reference yield:

: 23138-55-8
3-Bromophenyl isocyanate

: 1251899-84-9
1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 5.25 h / 5 - 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 100 °C / Inert atmosphere

3: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

4: hydroxylamine hydrochloride; pyridine / ethanol

5: caesium carbonate / dimethyl sulfoxide / 1 h / 20 °C

6: ISOPROPYLAMIDE / 18 h / 20 °C

With pyridine; potassium phosphate; hydroxylamine hydrochloride; potassium acetate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide;

Reference yield:

: 874299-21-5
1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(2,2,2-trifluoro-ethyl)-urea

: 1251899-84-9
1-{3-[7-({2-[(2-hydroxyethyl)methylamino]ethoxyimino}methyl)imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere

2: hydroxylamine hydrochloride; pyridine / ethanol

3: caesium carbonate / dimethyl sulfoxide / 1 h / 20 °C

4: ISOPROPYLAMIDE / 18 h / 20 °C

With pyridine; potassium phosphate; hydroxylamine hydrochloride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide;