4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

Base Information

Chemical Name:4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine
CAS No.:396072-79-0
Molecular Formula:C₂₃H₃₇N₃O₄
Molecular Weight:419.564
Hs Code.:

Synonyms:4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

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Chemical Property of 4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

Chemical Property:

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Technology Process of 4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

There total 6 articles about 4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 396072-78-9
4-({tert-butoxycarbonyl-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-amino}-methyl)-piperidine-1-carboxylic acid benzyl ester

: 396072-79-0
4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

Guidance literature:: With hydrazine hydrate; In ethanol; at 80 ℃;
DOI:10.1016/S0968-0896(01)00398-4

Reference yield:

: 7144-05-0
4-Aminomethylpiperidine

: 396072-79-0
4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / 1 h / 170 °C

2: 74 percent / NaOH / CH₂Cl₂; H₂O / 1 h / 20 °C

3: 100 percent / hydrazine monohydrate / ethanol / 80 °C

4: KF-Celite / acetonitrile / 50 °C

5: CH₂Cl₂ / 20 °C

6: 100 percent / hydrazine monohydrate / ethanol / 80 °C

With potassium fluoride; sodium hydroxide; hydrazine hydrate; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0968-0896(01)00398-4

Reference yield:

: 157023-34-2
4-aminomethyl-piperidine-1-carboxylic acid benzyl ester

: 396072-79-0
4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: KF-Celite / acetonitrile / 50 °C

2: CH₂Cl₂ / 20 °C

3: 100 percent / hydrazine monohydrate / ethanol / 80 °C

With potassium fluoride; hydrazine hydrate; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/S0968-0896(01)00398-4