5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Name:5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
CAS No.:1089145-69-6
Molecular Formula:C₃₄H₃₆N₄O₄
Molecular Weight:564.684
Hs Code.:

Synonyms:5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Property of 5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Technology Process of 5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

There total 9 articles about 5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156232-24-5
5-(benzyloxy)-1,3-dihydro-2H-indol-2-one

: 1089146-41-7
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

: 1089145-69-6
5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: With pyrrolidine; In ethanol; for 1.5h; Heating / reflux;

Reference yield:

: 31949-21-0
bromomethyl 2-methoxyphenyl ketone

: 1089145-69-6
5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether / 20 °C

2.1: hydrogenchloride / ethanol; water / 48 h / 20 °C

3.1: sodium acetate / water / 2 h / 80 °C

4.1: trichlorophosphate / dichloromethane / 20 °C

4.2: 1 h / Heating / reflux

4.3: 24 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

5.2: 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

7.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

8.1: pyrrolidine / ethanol / 1.5 h / Heating / reflux

With pyrrolidine; hydrogenchloride; sodium hydroxide; water; sodium acetate; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: 34589-97-4
2-amino-1-(2-methoxyphenyl)ethan-1-one hydrochloride

: 1089145-69-6
5-{(Z)-[5-(benzyloxy)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]methyl}-N-[2-(diethylamino)ethyl]-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate / water / 2 h / 80 °C

2.1: trichlorophosphate / dichloromethane / 20 °C

2.2: 1 h / Heating / reflux

2.3: 24 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

3.2: 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

5.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

6.1: pyrrolidine / ethanol / 1.5 h / Heating / reflux

With pyrrolidine; sodium hydroxide; water; sodium acetate; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water;