N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Name:N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide
CAS No.:1089146-41-7
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Chemical Property of N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

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Technology Process of N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

There total 8 articles about N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1089146-40-6
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

: 1089146-41-7
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: N-[2-(diethylamino)ethyl]-5-formyl-4-(2-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 31949-21-0
bromomethyl 2-methoxyphenyl ketone

: 1089146-41-7
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether / 20 °C

2.1: hydrogenchloride / ethanol; water / 48 h / 20 °C

3.1: sodium acetate / water / 2 h / 80 °C

4.1: trichlorophosphate / dichloromethane / 20 °C

4.2: 1 h / Heating / reflux

4.3: 24 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

5.2: 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

7.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; water; sodium acetate; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: 1-[2-(2-methoxyphenyl)-2-oxo-ethyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane bromide

: 1089146-41-7
N-[2-(diethylamino)ethyl]-5-formyl-4-(2-hydroxyphenyl)-2-methyl-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 48 h / 20 °C

2.1: sodium acetate / water / 2 h / 80 °C

3.1: trichlorophosphate / dichloromethane / 20 °C

3.2: 1 h / Heating / reflux

3.3: 24 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 9 h / 80 °C

4.2: 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 1.5 h / 20 °C

6.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; water; sodium acetate; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water;